Neglect the nibbles: how marijuana could be an urge for food suppressant


The ability of marijuana to stimulate the appetite is well documented. And no, we are not talking about the "nibbles". We refer to his ability to boost appetite in potentially life-threatening situations.

For example, cancer in patients can lead to adverse metabolic changes that cause them to lose their appetite and tissue, leading to a condition called “cachexia”. Chemotherapy and cancer medication often potentiate these effects, but research shows that medicinal cannabis can increase appetite, mood, and calorie intake in cancer patients while fighting cancer cells.

AIDS patients similarly suffer from wasting syndrome, in which someone loses more than 10% of their body weight. Several studies have reported increased appetite and decreased symptoms of nausea in HIV-positive people who used marijuana compared to those who took a placebo.

This positive effect on appetite is mainly associated with THC, the psychoactive cannabinoid in the cannabis plant. Marijuana contains at least 113 cannabinoids, and one of them has received new attention due to its opposite effect – suppressing appetite and potentially improving energy levels.

It's called THCV and is similar to THC. The two cannabinoids share psychoactive elements and molecular structures, but their differences have led to intrigue in the scientific community.

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In a 2018 molecular biological study, THCV was described as the “anomaly” of the cannabis plant and is the only known phytocannabinoid that acts as an antagonist of the CB1 receptors in your body's endocannabinoid system. A 2015 study published in the International Journal of Neuropsychopharmacology reported that low doses of THCV could counteract some of the mind-altering, intoxicating effects of THC and potentiate others.

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What was most surprising was that the antagonistic effects of THCV reversed appetite than THC. The mechanism works like this: THCV triggers your brain, especially the amygdala region, to associate types of food consumption with an uncomfortable feeling. The more you ate, the less you would enjoy it, according to the study. This applies in particular to fatty, fatty foods.

"Due to the increasing tendency of the appetite regions to classify food as unpleasant, this effect can shorten the time to feeling full, since food becomes unpleasant when consumed repeatedly, which in turn reduces overall consumption," the authors of the study write.

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This has prompted others to suggest THCV as a possible obesity tool without the possible side effects such as anxiety, depression, and insomnia that are present in current obesity drugs.

The only problem? Most cannabis strains only produce traces of THCV. Some companies have started replicating the cannabinoid in commercial laboratories, although their product is not yet widely available.

If you want to experiment with THCV now, you shouldn't be afraid. Research shows that THCV is most common in sativas, typically those originating in Africa. Ask your budtender in the pharmacy whether he has African hybrids. Other strains that are known to contain higher THCV are Doug & # 39; s Varin, Girl Scout Cookies, and Durban Poison.


Beth Edmonds