The endocannabinoid system explains – why hashish is nice for our physique


Cannabis has recently been used as a treatment option for many different diseases, many of which appear to be completely independent. From physical pain to mental disorders to cancer, everything is said to respond to cannabinoid treatments, but how exactly is that possible?

When you first hear about all the different conditions under which medical cannabis is used today, it almost seems to be a gimmick that needs to be legalized. Can a plant, not to mention a plant that takes you high, seriously have so many therapeutic benefits? Although it seems like a stretch, it makes a lot more sense why cannabis actually works so well in the human body if you understand the endocannabinoid system.

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What is the endocannabinoid system?

The only reason cannabis actually works and affects us at all is the endocannabinoid system (ECS). Simply put, the ECS is a network of receptors that are present in the body of all mammals and the endocannabinoids that bind to them. Overall, the ECS regulates numerous different functions and processes in our body and maintains internal balance and homeostasis.

So far, researchers have discovered two different endocannabinoids, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). 2-AG is made from omega-6 fatty acids and is present in relatively large quantities in the central nervous system, but has also been detected in breast milk (and beef milk). 2-AG is a complete agonist of both the CB1 and CB2 receptors, but has a stronger impact on the CB2 receptor. For this reason, it is believed that 2-AG has a significant impact on the immune system.

Anandamide (AEA), also commonly referred to as the "bliss molecule", is believed to play an important role in all of our basic daily physiological functions, including sleep / wake cycles, appetite, mood, and even fertility. However, we will consider the benefits of this cannabinoid in more detail later.

In addition to the naturally produced cannabinoids, there is also a large network of receptors that allow AEA and 2-AG to function the way they do. The two most extensively studied receptors are CB1 and CB2. Cannabinoid receptors sit on the surface of cells and monitor the external conditions. Once they find that conditions change and the body falls out of a state of homeostasis, they signal the appropriate cellular response to restore balance.

Anandamide: the lucky molecule

Although two endocannabinoids are known, one is far more important in research and literature: anandamide (AEA). The reason why AEA is known as the bliss molecule is because of the role it plays in balancing our body functions and increasing our mood. Several studies have been conducted on the benefits of exposure to different anandamide levels.

Anandamide – The "bliss" molecule of the endocannabinoid system

In 2015, a study that looked at both humans and rodents found that high anandamide levels contributed to mood elevation and anxiety reduction. When the enzymes that break down anandamide were inhibited, the subjects felt less anxiety and restlessness when threats were perceived.

A 2009 study linked anandamide to fertility by showing that high concentrations of this endocannabinoid are not only beneficial but also essential for regular ovulation and proper fetal development. The study also concluded that higher levels of anandamide during ovulation contributed to a healthy and successful pregnancy.

A slightly older study from 2004 found that an increased level of anandamide in the bloodstream led to a "euphoric high" in people who had just carried out rigorous exercises or physical activities. This is often referred to as "Runner's High" or "Adrenaline High". This is probably the reason why people who use cannabis often feel that this contributes to their training.

Although this is one of the best-studied cannabinoids, much is unknown about the happiness molecule about the extent of its functions.

Clinical endocannabinoid deficiency

Clinical endocannabinoid deficiency is a recently discovered disease, some still call it a theory in which the body does not produce enough endocannabinoids. As a result, the body is out of balance and numerous different diseases and disorders occur.

According to the recognized cannabinoid researcher Dr. Ethan Russo can greatly benefit people diagnosed with clinical endocannabinoid deficiency by supplementing them with phytocannabinoids – cannabinoids from plants.

Do you have clinical endocannabinoid deficiency?

"Migraines, fibromyalgia, irritable bowel syndrome and related diseases have frequent clinical, biochemical and pathophysiological patterns that indicate clinical endocannabinoid deficiency that can be adequately treated with cannabinoid drugs," Russo mentioned in his 2004 study. This research was done Checked and repeated a few times during 2014 and 2016.

The above conditions have the greatest indication that they were caused by clinical endocannabinoid deficiency. However, there is an extensive and varied list of disorders that are likely related to this condition. These include failure to thrive in newborns, cystic fibrosis, causalgia, brachial plexopathy, phantom pain, childlike colic, glaucoma, dysmenorrhea, hyperemesis gravidarum, unexplained repeated miscarriages, post-traumatic stress disorder, bipolar disease and the list goes on.

Neurological disorders have also been linked to a lack of natural endocannabinoids. Some experts believe that cannabinoids can treat Alzheimer's, Parkinson's, and similar conditions. This could be the reason why people who suffer from these conditions report successes in self-medication with cannabis products.

Final thoughts

If you look at the whole picture and see how integrated cannabinoids are in almost every system in our body, it makes perfect sense why cannabinoid-based therapies are so successful in treating so many different diseases. The endocannabinoid system plays a role in all of our basic bodily functions. So if you are out of balance, can't eat properly, can't sleep, suffer from anxiety, etc., the right mix of cannabinoids may be more effective than chemical medicines in relieving your ailments and symptoms.

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Beth Edmonds