The whole lot that you must find out about kratom
Kratom (Mitragyna speciosa) is a flowering evergreen tree related to the coffee plant. It is native to Southeast Asia but is enjoying increasing popularity in Western culture for its stimulating and pain relieving effects. Kratom is used both recreationally and therapeutically and, like cannabis, is incredibly controversial.
For some time now, the US Drug Enforcement Agency has been trying to add kratom to the list of controlled substances in Appendix I. The government information available, as well as a handful of misdirected university studies, make kratom a “dangerous” plant with no known medicinal benefits. As a lifelong cannabis user and someone who has watched weeds go from being illegitimate and “dangerous” to being a trendy wellness product, I can safely say that we don’t get the full story about kratom either.
When it comes to firsthand reviews from others, as well as my personal experiences with the plant and the hundreds of reviews I’ve read online, everything suggests that kratom has therapeutic benefits that are worth investigating . In fact, the most common consumer concern had nothing to do with the facility itself, but rather what will happen to them when they no longer have access to kratom products.
Kratom is made up of a dozen alkaloids, compounds known to have medicinal value and which have been independently studied for decades. Quite a few independent studies have determined the pharmaceutical potential of kratom.
That is not to say that there are no risks. However, as with any consumable item, some people may experience unexpected adverse effects, but the vast majority cannot. For the most part, people largely support the use of kratom and believe that it is vital to the quality of their lives – and when people speak, I think it’s important that we listen.
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The chemistry behind the plant
While the scientific literature on kratom is scarce, it has been around for some time and has attracted the interest of a select few researchers from around the world. What we do know is that a total of 26 alkaloids have been isolated from kratom and many of these compounds have been studied individually.
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. They are produced by a wide variety of organisms including bacteria, fungi, plants and animals and can be purified from crude extracts of these organisms by acid-base extraction or solvent extractions followed by silica gel column chromatography. Alkaloids have a wide range of pharmacological activities and a great deal of research to support this.
The most common alkaloid in kratom is mitragynine, and it was considered the most potent for decades. In 2002, a group of Japanese researchers found that a variant called 7-hydronitragynine had been discovered. This side compound is extremely potent, stronger than morphine, and while only present in trace amounts, it is responsible for most of the pain relieving properties of kratom. Further research has shown that both alkaloids act as partial opioid receptor agonists by activating the supraspinal mu and delta opioid receptors.
Kratoms have many chemical compounds
The alkaloid structure of kratom shares many similarities with those of other psychedelics like LSD and psilocybin, but no mind-altering effects of this type have been reported even after using kratom. Rather, kratom can be energizing and focus-enhancing at low doses, and act as a depressant at higher doses. Regardless of the amount consumed, some pain relief can also be expected thanks to the many alkaloid compounds in kratom.
The researchers were able to isolate the following 26 alkaloids from kratom: ajmalicin, 7-acetoxymitragynin, corynantheidin, corynoxein, corinoxin, 3-dehydromitragynin, (-) – epicatechin, 3-isocorynantheidin, 3-isopaynanthein, isomragynaphylline, isospaynaphylline, isospaynaphylline, isospaynaphylline , Mitraphylin, Mitraspecin, Mitraversin, Paynanthein, Speciociliatin, Speciofolin, Speciogynin, Specionoxein, Speciogynin, Speciofolin and Stipulatin.
In total, kratom actually contains over 40 chemical compounds, but we’re going to narrow it down to the three main ones, 7-hydroxymitragynine, mitragynine, and (-) – epicatechin.
7-Hydroxymitragynine is technically a minor compound in kratom, but it is by far the most potent, making it the main ingredient in kratom powders and other products. This alkaloid has opioid agonistic activity and interacts with the three main opioid sites kappa, delta and mu.
Mitragynine is an indole alkaloid that was first isolated by D. Hooper in 1907. It’s the most abundant compound in kratom and was considered the most potent until 2002, though the latter turned out not to be. Small doses bind to the delta receptors and act as a stimulant, while larger doses bind to the mu receptors and have a calming effect.
(-) – EPICATECHIN
Epicatechin is a versatile flavanol that has anti-inflammatory effects and can help protect against free radicals. Epicatechin is one of the most abundant flavonoids found in various fruits such as apples, blackberries, broad beans, cherries, grapes, pears, raspberries, cocoa and tea leaves.
History of Kratom Use
The use of kratom goes back centuries and it’s hard to argue with a plant that has been around for so long and is represented by so many people from different regions and cultures.
As with most existing natural and holistic remedies, kratom use can be traced back to traditional Eastern medicine. In the past, in regions such as the Philippines and New Guinea, the chopped leaves were chewed or brewed into tea by local artisans, who needed to avoid fatigue and improve productivity at work. In addition, various kratom supplements have been used during social and religious ceremonies and for the treatment of a wide variety of diseases.
Kratom was first mentioned in Western literature in the early 19th century, but the Dutch botanist Willem Korthals who worked for the East India Company, an English company founded to take advantage of trading options between the Middle East, Southeast Asia and India. Researcher EM Holmes also referred to kratom’s use as an opium substitute, specifically identifying it as Mitragyna speciosa in 1895.
Again, official studies on kratom are lacking, but a recent survey of more than 2,700 self-reported users conducted by Johns Hopkins University found that a large majority of people use this plant for pain relief. They also concluded that kratom “is likely to have a lower rate of harm and abuse” than prescription opioids, which are responsible for nearly 50,000 deaths each year in the US.
In a report of the results published in the February 3 issue of Drug and Alcohol Dependence, the researchers warned, “While self-reporting surveys are not always completely reliable, they have confirmed that kratom is not regulated by US food or and Drug Administration (FDA), and that no scientific studies have been conducted to formally demonstrate safety or benefit. “
According to the American Kratom Association (AKA), a consumer protection group, an estimated 10 to 16 million people in the United States use kratom regularly. Kratom is full of alkaloids that are present in many aspects of human life, including much of what we consume. Alkaloids have anti-inflammatory, Anti cancer, Analgesics, local anesthetics and Pain Relief, neuropharmacological, antimicrobial, antifungal and many other activities
The benefits of using kratom include but are not limited to: increased mood, increased energy, healthy and restful sleep, increased energy, muscle relaxation, natural aphrodisiac, social anxiety relief, pain relief, and minimization of withdrawal symptoms from illegal drugs.
Risks and Side Effects
The jury is not yet sure exactly what the risks of kratom are and whether or not they outweigh the benefits. Unsuspecting researchers with no firsthand experience of the plant say “yes” the risks are far too great, while anecdotes from people who have been using kratom regularly for years say “no” it is perfectly safe and beneficial for you general well-being and quality of life.
That said, some people actually have negative reactions to kratom such as high blood pressure and seizures. I think it’s important to emphasize that this can happen to anything, just as people can have allergic or other physical reactions to perfectly healthy foods and natural compounds.
Poison control data says that US call centers received around 1,800 reports between 2011 and 2017 of kratom use – though many of them were more of a combination of paranoia and hypochondria than real physical symptoms. Additional side effects can include dry mouth, dizziness, drowsiness, hallucinations, shortness of breath, and chills.
Similar to other pain relievers, problems with negative side effects typically arise when kratom is used in unusually high doses or for a long period of time. From what I’ve read, all negative experiences with kratom have been related to the use of highly concentrated extracts, not the bulk products or teas used by most people.
Now that you know more about the insides of this natural pain reliever, you are probably wondering if kratom is right for you. Ultimately, it’s up to you to choose, but it is certainly a sought-after, natural pain reliever for anyone who doesn’t have a disease that prevents them from using kratom.
What is your experience with the plant? What are your favorite kratom products? If you have an opinion on this, we’d love to hear more from you! Drop us a line in the comments section below and don’t forget to subscribe to the weekly CBD Flowers newsletter for more information on flowers and exclusive offers on flowers and other products.
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