THC

Why mice are excellent for marijuana analysis

why-mice-are-excellent-for-marijuana-analysis

The problem with doing full research in the cannabis laboratory is that it’s still illegal at the federal level in the U.S. Anymeaningful research In the US, marijuana is focused on CBD and other cannabinoids rather than THC.

But other countries that have no restrictions on marijuana are studying laboratory research using mice. And some of the recent results are amazing.

Why mice?

About 95%Of all laboratory animals, mice and rats are used in some of the world’s most important research. For example, research with mice led to aDrug used to treat breast cancer this improved long-term survival by 9%.

Mice are anatomically, physiologically and genetically similar to humans. They are social beings and can have the same reactions as humans when exposed to substances like marijuana.

A study concluded that some genetically engineered mice might be the best way to study the psychoactive effects of marijuana on humans, including feelings of relaxation and socializing.

Humans and mice shareabout 95% of their 30,000 genesand researchers are working on it“Humanize” mice Carrying human genes, cells, tissues or organs for further study of human diseases and the effects of therapeutic treatments such as cannabis.

Mice reproduce and mature quickly and only live about 2 years. This makes them ideal for measuring the entire lifespan of an animal. For comparison: With a dog or a monkey, the results would take 15 to 30 years for a lifetime.

RELATED: Understanding the Importance of Marijuana Studies and Findings

The mice’s short lifespan was key to recent marijuana research that found that aging was reversed in mice, with potential uses for treating people with Alzheimer’s disease and dementia.

ONPress release Through the work of scientists from the University of Bonn and the Hebrew University of Jerusalem (Israel), who have no government restrictions on the use of THC for medical research, it was found that the control group of mice had “pronounced cognitive deficits” as early as twelve months of age . The researchers gave the affected group of mice low levels of THC for four weeks at two, twelve, and 18 months.

Photo by CasarsaGuru / Getty Images

What they found was that the 18-month-old control mice showed signs of memory loss, while the 18-month-old subjects who were treated with THC actually retained their two-month-old memory capacity.

One of the chief researchers at the University of Bonn, Andreas Zimmer, commented on the results: “It looked as if the THC treatment would turn back the molecular clock.”

RELATED: Why Is The DEA Pulling Its Feet Up To Approve Marijuana Suppliers For Research Use?

The results of the University of Bonn / Hebrew University of Israel mouse tests have encouraged scientists to consider the next step in the research process: using human subjects. According to Federal Minister of Science Svenja Schulze, this will take some time. “While there is a long road from mice to humans, I see the prospect of THC being used to treat dementia extremely positive.”

There is more to come that could make mice even better animals to use in human marijuana research from the EUResource and research center for mutant mice at the University of Missouri. Her mission is to provide biomedical researchers with the mouse models, embryonic stem cells, related reagents, and protocols they need for their research.

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Beth Edmonds